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KMID : 0928320080080030194
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Korean Journal of Health Promotion and Disease Prevention
2008 Volume.8 No. 3 p.194 ~ p.200
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Metabolic Syndrome and Chronic Kidney Disease
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Choi Jae-Kyung
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Abstract
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Background: The significance of metabolic syndrome has been raised as a risk factor in chronic kidney disease. We examined the association between metabolic syndrome and its components and chronic kidney disease in adults.
Methods: A total of 5453 subjects who participated in the Korean National Health and Nutrition Examination survey 2001 were included. Metabolic syndrome was defined as the presence of 3 or more of the following components: abdominal obesity, elevated blood pressure, elevated glucose level, high triglyceride level, and low high-density lipoprotein cholesterol level according to the criteria of the American Heart Association/National Heart, Lung, and Blood Institute(AHA/NHLBI). Chronic kidney disease was defined as dipstick-positive proteinuria(≥1+) or a estimated glomerular filtration rate less than 60mL per 1.73m2.
Results: Compared with the odds ratios of the each components of metabolic syndrome, the crude odds ratio of the chronic kidney disease in subjects with the elevated blood pressure compared with subjects without the elevated blood pressure was 3.31(95% CI, 2.68 to 4.09) and the multivariate-adjusted odds ratio in subjects with the high triglyceride level compared with subjects without the high triglyceride level was 1.64(95% CI, 1.28 to 2.09). In subjects with metabolic
syndrome compared with subjects without metabolic syndrome, the crude and multivariate-adjusted odds ratios of chronic
kidney disease were 3.21(95% CI, 2.60 to 3.96) and 1.65(95% CI, 1.29-2.12) (p<0.001).
Conclusions: Metabolic syndrome might be an important risk factor of chronic kidney disease, independently of age, sex, education level, monthly income, current smoking, at-risk drinking, and regular exercise.
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KEYWORD
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metabolic syndrome, chronic kidney disease, risk factor, glomerular filtration rate
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